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Advances in Mitochondrial Medicine - download pdf or read online

By Sergio Papa, Pietro Luca Martino, Giuseppe Capitanio, Antonio Gaballo (auth.), Roberto Scatena, Patrizia Bottoni, Bruno Giardina (eds.)

Mitochondria are way over the “powerhouse” of the mobilephone as they've got classically been defined. in truth, mitochondria organic actions have steadily multiplied to incorporate not just numerous bioenergetic techniques but additionally very important biosynthetic pathways, calcium homeostasis and thermogenesis, phone loss of life by means of apoptosis, numerous diverse sign transduction pathways almost always with regards to redox regulate of gene expression etc. This useful and structural complexity might suffer vital derangements so that you can justify the definition of ‘mitochondrial medicine’, which should still comprise the entire scientific results of congenital or got mitochondrial dysfunctions. There are literally more and more reviews which assign an important pathogenic position to broken mitochondria in numerous illnesses: ischemia/reperfusion damage, neurodegenerative ailments, melanoma with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, simply to point out a number of the most vital pathologies. during this context, an extra element that are supposed to no longer be omitted is the interplay of pharmacological brokers with mitochondria, not just in regard of the toxicological facets yet, peculiarly, of the capability healing purposes. in reality, it really is attention-grabbing to notice that, whereas the houses of other so-called “mitoxicants” are recognized, the delicate linkages among medications and mitochondria remains to be short of a true pharmacological and healing keep watch over on the medical point. This loss of attention can frequently bring about an irony of undesirable poisonous results but additionally of fascinating healing actions. A reevaluation of the aptitude scientific function of mitochondria may provide a brand new mild on a few but vague facets of human pathophysiology.

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Mol Cell Biol 27:4228–4237 Leaver CJ, Lonsdale DM (1989) Mitochondrial biogenesis. Cambridge University Press, London Lee HM, Das TK, Rousseau DL, Mills D, Ferguson-Miller S, Gennis RB (2000) Mutations in the putative H-channel in the cytochrome c oxidase from Rhodobacter sphaeroides show that this channel is not important for proton conduction but reveal modulation of the properties of heme a. Biochemistry 39(11):2989–2996 Lee J, Kim CH, Simon DK, Aminova LR, Andreyev AY, Kushnareva YE, Murphy AN, Lonze BE, Kim KS, Ginty DD, Ferrante RJ, Ryu H, Ratan RR (2005) Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival.

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FEBS Lett 545(1):9–17 Brix J, Rudiger S, Bukau B, Schneider-Mergener J, Pfanner N (1999) Distribution of binding sequences for the mitochondrial import receptors Tom20, Tom22, and Tom70 in a presequence-carrying preprotein and a non-cleavable preprotein. J Biol Chem 274:16522–16530 Brown GC (1999) Nitric oxide and mitochondrial respiration. Biochim Biophys Acta 1411(2–3):351–369 Brzezinski P, Gennis RB (2008) Cytochrome c oxidase: exciting progress and remaining mysteries. J Bioenerg Biomembr 40:521–531 Brzezinski P, Larsson G (2003) Redox-driven proton pumping by heme-copper oxidases.

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