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Download PDF by Professor Thomas Unger, Professor Bernward A. Schölkens: Angiotensin Vol. II

By Professor Thomas Unger, Professor Bernward A. Schölkens (auth.)

Nearly thirty years in the past, in 1974, the quantity on Angiotensin edited via Irvine H.Page and F. Merlin Bumpus increased the guide of Experimental Pharmacology. Even after 20 years the multiplicity of its activities seems to be to not were absolutely found. to name recognition to its many features is without doubt one of the reasons of this ebook. This re-creation of the amount on Angiotensin makes an attempt to supply an up-to-date account of the information and findings accrued because the complexity of angiotensin was once so competently recognized.

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42 43 44 44 47 48 49 51 52 Abstract Extracellular matrix (ECM) is an important structural and functional constituent of both healthy and diseased blood vessels. Vascular cells are embedded in the multicomponent network of the ECM that contains collagens, other glycoproteins, proteoglycans and carbohydrates. The interaction between embedded cells and ECM is mediated through specific transmembrane receptors such as integrins or syndecans.

With regard to development of atherosclerotic lesions, evidence from other animal models, including rodents and primates, showed that ACE inhibition may reduce the extent of vascular lesions (Chobanian et al. 1990; Hayek et al. 1995; Aberg and Ferrer 1990). Additional mechanisms by which the RAS, via ANG Il, may encourage the development of atherosclerosis and involve the activation of thrombosis pathways via PAl-1 (Ridker et al. 1993) and the stimulation of pro-inflammatory cytokines. PAl-1 serum levels in formerly healthy volunteers of the Physician Health Study were shown to be elevated and associated with a higher risk of myocardial infarction (Ridker and Vaughan 1995).

Induction of Autocrine Factors . . . . . Inhibition of ECM Turnover . . . . . Modulation of Focal Adhesion Signaling. . 4 Summary and Conclusion . 55 References . . . . . . . 2 11. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . 42 43 44 44 47 48 49 51 52 Abstract Extracellular matrix (ECM) is an important structural and functional constituent of both healthy and diseased blood vessels.

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