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New PDF release: Autoimmunity and the Pathogenesis of Diabetes

By Thomas Mandrup-Poulsen, Jørn Nerup (auth.), Fredda Ginsberg-Fellner M.D., Robert C. McEvoy M.D. (eds.)

It has been a problem for us to edit this quantity of Endocrinology and Metabo­ lism: growth in examine and medical perform. the subject of the pathogenesis of insulin-dependent, kind I diabetes mellitus is very acceptable for this sequence, due to the fact advances during this quarter were made, to a wide volume, by way of using state of the art laboratory options to scientific samples. over the past numerous years, a few traces of facts were accumulated, suggesting that vintage style I diabetes mellitus effects from the autoimmune des­ truction of pancreatic beta-cells in genetically vulnerable participants. This speculation is especially attractive since it bargains a rational method of the prevention of diabetes via immunosuppression. we have now attempted to give a balanced, authoritative precis of the data at present on hand to help the autoimmune speculation for the pathogenesis of human sort I diabetes, to put this data in ancient standpoint, to incorporate correct info from animal types of style I diabetes during which extra invasive experimentation is moral, and, ultimately, to replace the reader at the present prestige of makes an attempt to interfere within the development of diabetes with immunosuppressive medicines. manhattan, ny Fredda Ginsberg-Fellner Robert C. McEvoy Contents Preface.. . . .. .. .. . . . . . . . . . . . . ... . . . . . . . . . . . .. . . . . . . .. . . . . v individuals. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Xl . . . . . . . . . . . . . 1. The Autoimmune speculation of Insulin-Dependent Diabetes: 1965 to the current . . . . . . . . . . . . ..................... . . . . . .

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Stiller CR, Dupre J, Gent M, Jenner MR, Keown PA, Laupacis A, Martell R, Rodger 1. Autoimmune Hypothesis of Insulin-Dependent Diabetes 21 NW, Graffenried BV, Wolfe BMJ. Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset. Science 1984;223: 1362-1367. 20. Assan R, Feutren G, Debray-Sachs M, Quiniou-Debrie MC, Laborie C, Thomas G, Chatenoud L, Bach JE Metabolic and immunological effects of cyclosporin in recently diagnosed type 1 diabetes mellitus. Lancet 1985;i:67-71.

New Engl J Med 1985;313:353-360. 92. Like AA, Forster RM, Woda BA, Rossini AA. T-cell subsets in islets and lymph nodes of Bio Breeding/Worcester (BB/W) rats. Diabetes 1983;32 (supp!. 1):5IA. 93. Dean BM, Walker R, Bone AJ, Baird JD, Cooke A. Pre-diabetes in the spontaneously diabetic BB/E rat: Lymphocyte subpopulations in the pancreatic infiltrate and expression of rat MHC class IT molecules in endocrine cells. Diabetologia 1985;28:464-466. 94. Kolb-Bachofen V, Kolb H. New concept of insulitis and B-islet cell destruction.

148. Luger A, Schemthaner G, Urbanski A, Luger TA. Cytokine production in patients with newly diagnosed insulin dependent (type diabetes mellitus. Eur J Clin Invest 1988; 18:233-236. n 2 Immunogenetics and the Pathogenesis of Insulin-Dependent Diabetes Mellitus PABLO RUBINSTEIN Clinicians have long suspected that diabetes includes different disease entities. l These comments, as well as more modern clinical observations, were substantiated in the early 1970s when unambiguously distinct genetic backgrounds for type I and type II diabetic patients were reported.

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