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Download e-book for kindle: Biodrug Delivery Systems: Fundamentals, Applications and by Mariko Morishita, Kinam Park

By Mariko Morishita, Kinam Park

Biodrug supply platforms: basics, purposes and medical Development provides the paintings of a world staff of best specialists in drug improvement and biopharmaceutical technological know-how who talk about the most recent advances in biodrug supply structures and linked options. The publication discusses elements of winning formula, supply, and construction of biodrugs, which come with subtle vegetation and complicated procedures, a well-trained and an expert employees, and correct qc. furthermore, the authors examine:

  • ADME (Absorption, Metabolism, Distribution, and removing of biodrugs)
  • Directing and influencing the winning improvement of presently advertised best-selling biodrugs
  • Routes of management
  • Mechanisms of biodrug absorption
  • Alternative percentages for drug supply routes
  • Formulationson the industry from the viewpoint of team of workers keen on biodrug development

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Additional info for Biodrug Delivery Systems: Fundamentals, Applications and Clinical Development (Drugs and the Pharmaceutical Sciences)

Sample text

Almeida AJ, Souto E. Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Adv Drug Deliv Rev 2007; 59(6):478–490. 20. Reubsaet JL, Beijnen JH, Bult A, et al. Analytical techniques used to study the degradation of proteins and peptides: physical instability. J Pharm Biomed Anal 1998; 17(6–7):979–984. 21. Kauzmann W. Some factors in the interpretation of protein denaturation. Adv Protein Chem 1959; 14:1–63. 22. Dickinson E. Proteins in solution and at interfaces. In: Goddard ED, Ananthapadmanabhan KP, ed.

This implies that biopharmaceuticals for systemic treatment are administered parenterally, although efforts are made to improve bioavailability via alternative routes of administration as for instance the nasal, pulmonary, and oral route (3–5). A crucial issue to consider is how to overcome the biological barriers, regardless of whether the drug delivery system is administered to a patient by parenteral or nonparenteral routes of delivery or for aiming at systemic effects. Potential biological barriers are illustrated in Figure 1.

Jaenicke R. Protein stability and molecular adaptation to extreme conditions. Eur J Biochem 1991; 202(3):715–728. 28. Tanford C. Protein denaturation. Adv Protein Chem 1968; 23:121–282. 29. Bam NB, Cleland JL, Randolph TW. Molten globule intermediate of recombinant human growth hormone: stabilization with surfactants. Biotechnol Prog 1996; 12(6): 801–809. 30. Manning M, Patel K, Borchardt RT. Stability of protein pharmaceuticals. Pharm Res 1989; 6(11):903–918. 31. Dobson CM. Unfolded proteins, compact states and molten globules.

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