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Biological Toxins and Bioterrorism: Biological Toxins and - download pdf or read online

By P. Gopalakrishnakone (eds.)

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Extra resources for Biological Toxins and Bioterrorism: Biological Toxins and Bioterrorism

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Lacy DB, Tepp W, Cohen AC, DasGupta BR, Stevens RC. Crystal structure of botulinum neurotoxin type A and implications for toxicity. Nat Struct Biol. 1998;5(10):898–902. Li B, Pai R, Cardinale SC, Butler MM, Peet NP, Moir DT, Bavari S, Bowlin TL. Synthesis and biological evaluation of botulinum neurotoxin a protease inhibitors. J Med Chem. 2010;53(5):2264–76. Moe ST, Thompson AB, Smith GM, Fredenburg RA, Stein RL, Jacobson AR. Botulinum neurotoxin serotype A inhibitors: small-molecule mercaptoacetamide analogs.

These include clinical uses of restricted agents for diagnostic reference, diagnostic verification, and evaluation of the proficiency of diagnostic tests. There are also exceptions for attenuated strains of restricted agents approved for vaccination purposes and for toxins whose cumulative quantities fall below certain limits (Balali-Mood et al. 2013; Ferguson 1997; Hamburg 2002). Biological Toxins The CDC places biological agents in categories for public health preparedness efforts based on the likelihood of their being used in a biological attack and on the severity of the consequences that would result from such an attack, with the understanding that small-scale attacks are more probable owing to the lesser degrees of complexity involved (Rotz et al.

Kumar R, Kukreja RV, Cai S, Singh BR. Differential role of molten globule and protein folding in distinguishing unique features of botulinum neurotoxin. Biochim Biophys Acta. 2014;1844(6):1145–52. Kumaran D, Rawat R, Ahmed SA, Swaminathan S. Substrate binding mode and its implication on drug design for botulinum neurotoxin A. PLoS Pathog. 2008a;4(9):e1000165. Kumaran D, Rawat R, Ludivico ML, Ahmed SA, Swaminathan S. Structure- and substrate-based inhibitor design for Clostridium botulinum neurotoxin serotype A.

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