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Download PDF by Rodney J. Y. Ho: Biotechnology and Biopharmaceuticals: Transforming Proteins

By Rodney J. Y. Ho

Biotechnology and Biopharmaceuticals: remodeling Proteins and Genes into medicinal drugs defines biotechnology from the point of view of prescribed drugs. the 1st part specializes in the method of remodeling a biologic macromolecule right into a healing agent, whereas the second one part offers a short evaluate of every type of macromolecule with recognize to physiological function and medical program. extra element is additionally supplied within the moment part for every FDA licensed, recombinantly derived biopharmaceutical for every class of macromolecule. the ultimate part appears to be like to the longer term and the recent advances that may improve our skill to improve new macromolecules into powerful biopharmaceuticals. This final part discusses a number of drug supply suggestions whereas additionally describing gene and cellphone remedy options.

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Several approved peptides and proteins, including insulin, enfuvirtide [14], and the recently approved pramlintide [15], are administered as SC injections. Following a SC injection, peptide and protein therapeutics may enter the systemic circulation either via blood capillaries or through lymphatic vessels [16]. In general, macromolecules larger than 16 kDa are predominantly absorbed into the lymphatic system, whereas those under 1 kDa are mostly absorbed into the blood circulation. Studies with recombinant human interferon a-2 a (rhIFN a-2 a) indicate that, following SC administration, high concentrations of the recombinant protein are found in the lymphatic system, which drains into regional lymph nodes [17].

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M. C. F. Blaschke. 2000. Optimizing the science of drug development: Opportunities for better candidate selection and accelerated evaluation in humans. J. Clin. Pharmacol. 40 : 803–814. , and M. Danhof. 1997. Relevance of the application of pharmacokinetic-pharmacodynamic modelling concepts in drug development. The ‘wooden shoe’ paradigm. Clin. Pharmacokinet. 32 : 259–267. M. Persky, G. Hochhaus, and B. Meibohm. 2004. Pharmacokinetic aspects of biotechnology products. J. Pharm. Sci. 93 : 2184–2204.

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