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By M. Gabriel Khan

Cardiac Drug remedy: seventh version updates and revises the 6th version in different respects. the hot variation contains six new chapters that care for ongoing controversies concerning the use of numerous typical medications. those chapters comprise the betablocker controversies, ACE inhibitor controversies, calcium antagonist controversies, high blood pressure controversies, center failure controversies, and Statin controversies.

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Get Cardiac Drug Therapy Khan PDF

Cardiac Drug treatment: seventh version updates and revises the 6th variation in different respects. the hot variation contains six new chapters that care for ongoing controversies concerning the use of numerous wide-spread medications. those chapters contain the betablocker controversies, ACE inhibitor controversies, calcium antagonist controversies, high blood pressure controversies, center failure controversies, and Statin controversies.

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Carvedilol has been shown in an RCT in patients with class II–III HF to decrease mortality and the risk of hospitalization for recurrent HF. Thus, approved beta-blockers have a new indication for the management of patients with LV dysfunction or class I–III HF. • In COPERNICUS (55), carvedilol produced a significant reduction in serious events in patients with compensated class IV HF, and the indication has been extended from class I to compensated class IV patients (see Chapters 12 and 22). • Most important, in MERIT-HF (56), only a small dose of a beta-blocking drug administered to patients in the low-dose subgroup achieved risk reduction similar to that observed in the high-dose subgroup.

Motomura S, Zerkowski HR, Daul A, et al. On the physiologic role of beta-2 adrenoceptors in the human heart: in vitro and in vivo studies. Am Heart J 1990;119:608. 11. Krum H, Gu A, Wiltshire-Clement M, et al. Changes in plasma endothelin-1 levels reflects clinical response to β-blockade in chronic heart failure. Am Heart J 1996;131:337. 12. Cruickshank JM, Degaute JP, Kuurne T, et al. Reduction of stress/catecholamine induced cardiac necrosis by B1 selective blockade. Lancet 1987;2:585. Chapter 1 / Beta-Blockers 33 13.

REFERENCES 1. Cruickshank JM. Beta-blockers continue to surprise us. Eur Heart J 2000;21:355. 2. Sixth Report of Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure. Arch Intern Med 1997;157:2413. 3. Khan M Gabriel. Hyperlipidemia. In: Heart Disease, Diagnosis and Therapy. Baltimore, Williams & Wilkins, 1996, p. 384. 4. Frishman WH. Beta-adrenergic blocking drugs. Am Coll Cardiol Curr J Rev 1997;23. 5. Black JW, Crowther AF, Shanks RG, et al. A new adrenergic beta-receptor-antagonist.

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